Albert Barnes Commentary 1 Samuel 22:19

"And Nob, the city of the priests, smote he with the edge of the sword, both men and women, children and sucklings, and oxen and asses and sheep, with the edge of the sword." — 1 Samuel 22:19 (ASV)

The language employed here, Both men and women, is the same as that used in the case of the Amalekites (1 Samuel 15:3) and of Jericho (Joshua 6:21). Nothing could be more savage than Saul’s revenge.