Albert Barnes Commentary Acts 10:38

"[even] Jesus of Nazareth, how God anointed him with the Holy Spirit and with power: who went about doing good, and healing all that were oppressed of the devil; for God was with him." — Acts 10:38 (ASV)

How God anointed, etc. This means God set Him apart for this work and was with Him, acknowledging Him as the Messiah.

With the Holy Ghost.

The act of anointing kings and priests seems to have been emblematic of the influences of the Holy Ghost. Here it means that God communicated to Him the influences of the Holy Spirit, thus setting Him apart for the work of the Messiah (John 3:34).

God giveth not the Spirit by measure unto him.

And with power. The power of healing the sick, raising the dead, etc.

Who went about doing good. His main business was to travel from place to place to do good. He did not go for applause, wealth, comfort, or ease, but to diffuse happiness as far as possible. This is the simple but sublime record of His life. This, in few but most affecting words, tells us all about the Savior. It gives us a distinct portrait of His character, as He is distinguished from conquerors and kings, false prophets, and the mass of people.

And healing, etc. Restoring to health.

All that were oppressed by the devil. That is, all who were possessed by him.

God was with Him. God appointed Him and, by His miracles, furnished the highest evidence that He had sent Him. His miracles were such that they could be performed only by God.