Albert Barnes Commentary Acts 14:6

"they became aware of it, and fled unto the cities of Lycaonia, Lystra and Derbe, and the region round about:" — Acts 14:6 (ASV)

They were aware of it. They were in some way informed of the excitement and of their danger.

And fled to Lystra. This was a city of Lycaonia, and was a few miles south of Iconium. It is now called Latik.

And Derbe. Derbe was a short distance east of Lystra.

Cities of Lycaonia. Lycaonia was one of the provinces of Asia Minor. It had Galatia north, Pisidia south, Cappadocia east, and Phrygia west. It was formerly within the limits of Phrygia, but was established as a separate province by Augustus.

And to the region, etc. The adjacent country. Though persecuted, they still preached; and though driven from one city, they fled into another. This was the direction of the Savior (Matthew 10:23).