Albert Barnes Commentary Colossians 4:2

"Continue stedfastly in prayer, watching therein with thanksgiving;" — Colossians 4:2 (ASV)

Continue in prayer. That is, do not neglect it; observe it at all stated times; maintain the spirit of prayer, and embrace all proper occasions to engage in it. Compare Luke 18:1; Ephesians 6:18; 1 Thessalonians 5:17.

And watch in the same with thanksgiving. Watch for favourable opportunities; watch that your mind may be in a right frame when you pray; and watch, that when your mind is in a right frame you may not neglect to pray. See Ephesians 6:1; Ephesians 6:8; Philippians 4:6.

The term "Continue" may also be rendered "Persevere." For "in prayer," see Luke 18:1. For "watch," see Mark 13:33.