Albert Barnes Commentary Isaiah 37:22

"this is the word which Jehovah hath spoken concerning him: The virgin daughter of Zion hath despised thee and laughed thee to scorn; the daughter of Jerusalem hath shaken her head at thee." — Isaiah 37:22 (ASV)

The virgin, the daughter of Zion - Jerusalem (see the note at Isaiah 1:8; compare the note at Isaiah 23:12). The parallelism in this and the following verses shows that the poetic form of speech is here introduced.

Hast despised thee - That is, it is secure from your contemplated attack. The idea is, that Jerusalem would exult over the ineffectual attempts of Sennacherib to take it, and over his complete overthrow.

Hath laughed thee to scorn - Will make you an object of derision.

Hath shaken her head at thee - This is an indication of contempt and scorn (Psalms 109:25; Jeremiah 18:16; Zephaniah 2:15; Matthew 27:39).