Albert Barnes Commentary Isaiah 51:22

"Thus saith thy Lord Jehovah, and thy God that pleadeth the cause of his people, Behold, I have taken out of thy hand the cup of staggering, even the bowl of the cup of my wrath; thou shalt no more drink it again:" — Isaiah 51:22 (ASV)

I have taken out of your hand the cup of trembling - (See the notes at Isaiah 51:17). This verse contains a promise that they would be delivered from the effect of the wrath of God, under which they had been suffering so long.

You shall no more drink it again - You shall no more be subject to similar trials and calamities . Probably the idea here is not that Jerusalem would never again be destroyed (which would not be true, for it was afterward subjected to more severe trials under the Romans), but that the people who would then return—the pious exiles—would be preserved forever after from similar sufferings. The object of the prophet is to console them, and this he does by the assurance that they should be subjected to such trials no more.