Albert Barnes Commentary Jeremiah 19:4

"Because they have forsaken me, and have estranged this place, and have burned incense in it unto other gods, that they knew not, they and their fathers and the kings of Judah; and have filled this place with the blood of innocents," — Jeremiah 19:4 (ASV)

Have estranged this place - They have not recognized the sanctity of this place, but have treated it as a strange place, by worshipping in it strange gods.

Innocents - that is, guiltless persons.