Albert Barnes Commentary Jeremiah 2:37

"From thence also shalt thou go forth, with thy hands upon thy head: for Jehovah hath rejected those in whom thou trustest, and thou shalt not prosper with them." — Jeremiah 2:37 (ASV)

From him - From it, from this Egypt, which though feminine as a land, yet as a people may be used as masculine . Now that Nineveh is trembling before the armies of Cyaxares and Nabopalassar, you hasten to Egypt, hoping to rest upon her strength: but you shall retrace your steps, with your hands clasped upon your head, disgraced and discarded.

Confidences - Those in whom you confide.

In them - Literally, “with respect to them.”