Albert Barnes Commentary Jeremiah 48:5

"For by the ascent of Luhith with continual weeping shall they go up; for at the descent of Horonaim they have heard the distress of the cry of destruction." — Jeremiah 48:5 (ASV)

Luhith was situated upon an eminence, and Jeremiah describes one set of weeping fugitives as pressing close upon another.

In the going down of Horonaim ... — Rather, in the descent of Horonaim they have heard the distresses of the cry of breaking, that is, the cry of distress occasioned by the ruin inflicted by the enemy. It was situated in a hollow, probably near the Dead Sea.