Albert Barnes Commentary Jeremiah 50:44-46

"Behold, [the enemy] shall come up like a lion from the pride of the Jordan against the strong habitation: for I will suddenly make them run away from it; and whoso is chosen, him will I appoint over it: for who is like me? and who will appoint me a time? and who is the shepherd that can stand before me? Therefore hear ye the counsel of Jehovah, that he hath taken against Babylon; and his purposes, that he hath purposed against the land of the Chaldeans: Surely they shall drag them away, [even] the little ones of the flock; surely he shall make their habitation desolate over them. At the noise of the taking of Babylon the earth trembleth, and the cry is heard among the nations." — Jeremiah 50:44-46 (ASV)

A similar application to Babylon of what was said of Edom (a reference in the margin).