Albert Barnes Commentary Job 19:13

"He hath put my brethren far from me, And mine acquaintance are wholly estranged from me." — Job 19:13 (ASV)

He has put my brethren - This is a new source of affliction that he had not referred to before: that God had caused all his children to be estranged from him—a calamity which he regarded as the crown of all his woes. The word rendered “my brethren” (אחי 'âchāy) properly means “my brothers”—but whether he means literally his brothers, or whether he intends it to be taken in a figurative sense as denoting his intimate friends, or those of the same rank in life or calling, it is impossible now to determine.

And my acquaintance - My friends—on whom I relied in time of calamity.

And verily estranged - They have forgotten me, and treat me as a stranger. What an accurate description this is of what often occurs! In prosperity a man will be surrounded by friends; but as soon as his prosperity is stripped away, and he is overwhelmed with calamity, they withdraw and leave him to suffer alone. Proud of his acquaintance before, they now pass him by as a stranger, or treat him with cold civility, and when he needs their friendship, they are gone.