Albert Barnes Commentary Job 19:21

"Have pity upon me, have pity upon me, O ye my friends; For the hand of God hath touched me." — Job 19:21 (ASV)

Have pity on me - A tender, pathetic cry for sympathy. "God has afflicted me, and stripped me of all my comforts, and I am left a poor, distressed, forsaken man. I make my appeal to you, my friends, and entreat you to have pity; to sympathize with me, and to sustain me with words of consolation." One would have supposed that these words would have gone to the heart, and that we should hear no more of their bitter reproofs. But the reality was far different.

The hand of God has touched me - has smitten me; or is heavy upon me. The meaning is that he had been subjected to great calamities by God, and that it was right to appeal now to his friends and expect their sympathy and compassion. On the usual meaning of the word translated here as "has touched" (נגעה nâga‛âh from נגע nâga‛), see the notes at Isaiah 53:4.