Albert Barnes Commentary Job 19:22

"Why do ye persecute me as God, And are not satisfied with my flesh?" — Job 19:22 (ASV)

Why do you persecute me as God? – As God has done. That is, without giving me any reason for it, accusing me of crimes without proof, and condemning me without mitigation. That there is an improper reflection on God here will be apparent to all. It accords with what Job frequently expresses when he speaks of God judging him severely, and is one of the instances which prove that he was not entirely perfect.

And are not satisfied with my flesh? – That is, you are not content that my body is subjected to inexpressible torment and is wholly wasting away, but you add to this the torment of the soul. Why is it not enough that my body is thus tormented, without adding the severer tortures of the mind?