Albert Barnes Commentary Job 20:22

"In the fulness of his sufficiency he shall be in straits: The hand of every one that is in misery shall come upon him." — Job 20:22 (ASV)

In the fullness of his sufficiency – When he seems to have an abundance.

He shall be in straits – Either by the dread of calamity or because calamity shall come suddenly upon him, and his property shall be swept away. When everything seemed to be abundant, he will be reduced to want.

Every hand of the wicked shall come upon him – Margin: “or, troublesome.” The meaning is that all that the wretched or miserable endure will come suddenly upon him. Rosenmuller suggests, however, that it means that all the poor, and all who had been oppressed and robbed by him, would suddenly come upon him to recover their own property and would scatter all that he had. The general meaning is clear: he will be involved in misery from every quarter or on every hand.