Albert Barnes Commentary Job 28:23

"God understandeth the way thereof, And he knoweth the place thereof." — Job 28:23 (ASV)

God understandeth the way thereof - These are undoubtedly the words of Job. The meaning is that the reason for the divine dispensations could be known only to God Himself. He had given no clue by which people could discover this. They might carry their investigations far into the regions of science; they could penetrate the earth and look at the stars, but still all their investigations fell short of disclosing the reasons for the divine dispensations. The secret was lodged in His bosom, and He alone could communicate it where and when He pleased. It may be added here that this is as true now as it was in the time of Job.

People have carried the investigations of science almost infinitely further than they did then, but still, by the investigations of science, they have by no means superseded the necessity of revelation or shed light on the great questions that have, in all ages, so much perplexed humanity. It is only by direct communication, by His Word and by His Spirit, that people can be made to understand the reason for the divine doings. Nothing is better established by the course of events than the truth on which Job here so much insists: that science cannot answer the questions of so much interest to humanity about the divine government.