Albert Barnes Commentary Lamentations 3:4

"My flesh and my skin hath he made old; he hath broken my bones." — Lamentations 3:4 (ASV)

Made old - Or, wasted: his strength slowly wasted as he pined away in sorrow.

He hath broken my bones - This clause completes the representation of the sufferer’s physical agonies. Here the idea is that of acute pain.