Albert Barnes Commentary Luke 11:49

"Therefore also said the wisdom of God, I will send unto them prophets and apostles; and [some] of them they shall kill and persecute;" — Luke 11:49 (ASV)

See Barnes on Matthew 23:29.

Also Matthew 23:30-36.

The wisdom of God. By the wisdom of God, here, is undoubtedly meant the Saviour himself. What he immediately says is not written in the Old Testament. Jesus is called the word of God (John 1:1), because he is the medium by which God speaks or makes his will known. He is called the wisdom of God, because by him God makes his wisdom known in creation (Colossians 1:13–18) and in redemption (1 Corinthians 1:30). Many have also thought that the Messiah was referred to in the 8th chapter of Proverbs, under the name of Wisdom.

I will send. See Luke 10:3; Matthew 10:16.

Shall slay. Compare to John 16:2; Acts 7:52, 59; James 5:10; Acts 12:2; 22:19; 2 Corinthians 11:24–25; 2 Chronicles 36:15–16.