Albert Barnes Commentary Psalms 119:143

"Trouble and anguish have taken hold on me; [Yet] thy commandments are my delight." — Psalms 119:143 (ASV)

Trouble and anguish - The word rendered “trouble” means affliction of any kind; the word rendered “anguish” would probably express that which results from being pressed, compressed, or confined. It properly refers to a situation where there is no room to move, and where we are hemmed in within a narrow place. The two words denote deep affliction.

Have taken hold on me - Margin, as in Hebrew, “found me.” This means they were in pursuit of me and have at last apprehended me. Trouble, anguish, death, are in pursuit of us all our lives and are never very far behind us. Often, when we least expect them, they suddenly come up to us and make us their victims.

Yet thy commandments are my delights - Despite this trouble, and in this trouble—no matter what comes—I have the same unfailing source of comfort, the truth of God; and despite what may occur, I still make God and his law the source of my happiness. See the notes at Psalms 119:24.