Albert Barnes Commentary Psalms 139:22

"I hate them with perfect hatred: They are become mine enemies." — Psalms 139:22 (ASV)

I hate them with perfect hatred - With no approval whatever of their conduct; with no sympathy for the evil they do; with no words of apology for their sinful acts; with entire disapprobation.

I count them mine enemies - As they are the enemies of God, so I regard them as my enemies. I do not wish to be associated with them, or to be regarded as one of them.