Albert Barnes Commentary Psalms 143:4

"Therefore is my spirit overwhelmed within me; My heart within me is desolate." — Psalms 143:4 (ASV)

Therefore is my spirit overwhelmed within me - See the notes at (Psalms 77:3). Compare (Psalms 42:5–7). His spirit was broken and crushed. He was in a state of despair as to any human help.

My heart within me is desolate - I have no comfort; no cheerfulness; no hope. My soul is like the waste desert where there is no water; where nothing grows; where there are only rocks and sands.