Albert Barnes Commentary Psalms 6:3

"My soul also is sore troubled: And thou, O Jehovah, how long?" — Psalms 6:3 (ASV)

My soul is also sore vexed - The word "soul" here is used in the sense in which it is commonly understood by us, as denoting the mind. The idea is that his sorrows were not merely those of the physical body. They had a deeper seat than even the bones. His mind, his soul, was also full of anguish, because of the circumstances that surrounded him and had caused these bodily afflictions.

But thou, O Lord - This is a broken sentence, as if he had begun an address to God but did not complete it. It is as if he had said, "Here I suffer and languish; my sorrows are deep and unmitigated; as for you, O Lord"—as if he were about to say that he had hoped God would intervene, or that His dealings were mysterious, or that they seemed strange or severe. But he ends the sentence with no language of complaint, but simply by asking "how long" these sorrows were to continue.

How long? - That is, how long will you leave me to suffer like this? How long shall my unmitigated anguish continue? How long will it be before you intervene to relieve me? The language implies that in his perception it was already a long time—as time usually seems long to a sufferer , and that he was constantly watching for God to intervene and help him. This is language that all people may be inclined to use on beds of pain and languishing. It seems indeed long to them now; it will, however, seem short when they look back on it from the glories of the heavenly world (Compare 2 Corinthians 4:17–18).