Albert Barnes Commentary Psalms 65:2

"O thou that hearest prayer, Unto thee shall all flesh come." — Psalms 65:2 (ASV)

O thou that hearest prayer - Who have revealed Yourself as a God hearing prayer—one of the leading characteristics of whose nature it is that You hear prayer. Literally, “Hearer of prayer, to You shall all flesh come.”

Nothing as applied even to God is more sublime and beautiful than the appellative “Hearer of prayer.” Nothing in His attributes is of more interest and importance to humankind. Nothing more indicates His condescension and goodness; nothing so much encourages us in the endeavor to overcome our sins, to do good, to save our souls, and to save the souls of others.

Dark and dismal would this world be if God did not hear prayer. The prospects of humankind would be gloomy, inexpressibly gloomy, if we did not have the assurance that God is a prayer-hearing God—if we could not come to God at all times with the assurance that it is His very nature to hear prayer, and that His ear is ever open to the cries of the guilty, the suffering, the sad, the troubled, and the dying.

Unto thee shall all flesh come - This means all people, as the word is evidently used here to denote humankind. The idea is that there is no other resource for us, no other help, no other refuge, but the God who hears prayer. No other being can meet our actual needs, and those needs are to be met only in connection with prayer.

All people are permitted to come to God in this way; all need His favor. All must perish unless, in answer to prayer, He interposes and saves the soul.

It is also true that the period will arrive on earth when all flesh—all people—will come to God and worship Him; when, instead of the scattered few who now approach Him, all nations, all the dwellers on continents and islands, will worship Him, will look to Him in trouble, will acknowledge Him as God, and will supplicate His favor.