Albert Barnes Commentary Psalms 88:8

"Thou hast put mine acquaintance far from me; Thou hast made me an abomination unto them: I am shut up, and I cannot come forth." — Psalms 88:8 (ASV)

Thou hast put away mine acquaintance far from me — The same ground of complaint, or expression of the depth of affliction, occurs elsewhere (Psalms 31:11; Psalms 38:11; Psalms 69:8). See also (Job 19:13–17).

Thou hast made me an abomination unto them — As something which they would avoid, or from which they would revolt and turn away—as we turn away from the body of a dead man, or from an offensive object. The word means properly an object to be detested or abominated, as things unclean (Genesis 43:32); or as idolatry (1 Kings 14:24; 2 Kings 16:3; 2 Kings 23:13).

I am shut up — As in prison; namely, by disease, as when one is confined to his house.

And I cannot come forth — I cannot leave my couch, my room, my house. Compare (Job 12:14).