Albert Barnes Commentary Revelation 14:19

"And the angel cast his sickle into the earth, and gathered the vintage of the earth, and cast it into the winepress, the great [winepress], of the wrath of God." — Revelation 14:19 (ASV)

And the angel thrust in his sickle into the earth. That is, into that part of the earth which might be represented by a vineyard, or the earth considered as having been the dwelling place of wicked men.

And cast it into the great wine-press of the wrath of God. See Isaiah 63:1-6. That is, the wine-press where the grapes are crushed, and where the juice (resembling blood) flows out, may be used as a symbol to denote the destruction of the wicked in the last day. And as the numbers will be immensely great, it is called the "great wine-press of Divine wrath."

The symbol appears to be used here with reference to both the color of the wine resembling blood and the pressure necessary to force it out; and, thus employed, it is one of the most striking emblems conceivable to denote the final destruction of the wicked.