Albert Barnes Commentary Revelation 2:22

"Behold, I cast her into a bed, and them that commit adultery with her into great tribulation, except they repent of her works." — Revelation 2:22 (ASV)

Behold, I will cast her into a bed. This is not a bed of ease, but a bed of pain. There is evidently a purpose to contrast this with her former condition. The harlot's bed and a sick bed are thus brought together, as they often are, in fact, in the dispensations of Providence and the righteous judgment of God. One cannot be indulged without leading, sooner or later, to the horrid sufferings of the other—and how soon, no one knows.

And them that commit adultery with her. These are those who are seduced by her doctrines into this sin: either those who commit it with her literally, or who are led into the same kind of life.

Into great tribulation. This means great suffering: disease of the body or tortures of the soul.

How often—how almost uniformly is this the case with those who live in this manner! Sooner or later, sorrow always comes upon the licentious.

God has demonstrated by some of his severest judgments, in forms of frightful disease, his displeasure at the violation of the laws of purity. There is no sin that produces a more withering and desiccating effect upon the soul than the one referred to here, none that is more certain to be followed by sorrow.

Except they repent of their deeds. It is only by repentance that we can avoid the consequences of sin. The word repent here evidently includes both sorrow for the past and abandonment of the evil course of life.