A.T. Robertson Commentary Luke 22:44

"And being in an agony he prayed more earnestly; and his sweat became as it were great drops of blood falling down upon the ground." — Luke 22:44 (ASV)

In an agony (εν αγωνια). It was conflict, contest from αγων. An old word, but only here in the N.T. Satan pressed Jesus harder than ever before.

As it were great drops of blood (ωσε θρομβο αιματος). Thick, clotted blood. An old word (θρομβο) common in medical works, but here only in the N.T. This passage (verses 43,44) is absent from some ancient documents. Aristotle speaks of a bloody sweat as does Theophrastus.