A.T. Robertson Commentary Revelation 8:4

"And the smoke of the incense, with the prayers of the saints, went up before God out of the angel`s hand." — Revelation 8:4 (ASV)

The smoke (ο καπνος). Old word, in N.T. only Ac 2:19; Revelation 8:4; 9:2f., 17f.; 14:11; 15:8; 18:9,18; 19:3. Here from the incense in the angel's hand.

With the prayers (ταις προσευχαις). So associative-instrumental case, but it may be dative as in verse 3 (for).