Charles Ellicott Commentary Colossians 1:21

"And you, being in time past alienated and enemies in your mind in your evil works," — Colossians 1:21 (ASV)

Alienated.—Not naturally aliens, but estranged. (See Note on Ephesians 2:12.)

By wicked works.—Properly, in your wicked works. The enmity of heart is not properly caused by wicked works, but shown in them, and probably intensified by reflex action through them.