Charles Ellicott Commentary Daniel 2:21

"And he changeth the times and the seasons; he removeth kings, and setteth up kings; he giveth wisdom unto the wise, and knowledge to them that have understanding;" — Daniel 2:21 (ASV)

Changes times— that is, He orders the events which occur at different times and seasons. Daniel refers to the dream which had been recently revealed to him, in which the changes of future times and seasons were depicted in so marvelous a way. “Times” are opposed to “seasons,” as circumstances of time may be contrasted with epochs of time. (Compare Daniel 7:12.)

He removes— Compare 1 Samuel 2:8.

Wisdom ... — Compare Jeremiah 32:19.

The wise — that is, wise men generally. Wise men become what they are, not through their own study and natural ability, but by the grace and mercy of God.