Charles Ellicott Commentary Isaiah 24:5

"The earth also is polluted under the inhabitants thereof; because they have transgressed the laws, violated the statutes, broken the everlasting covenant." — Isaiah 24:5 (ASV)

The earth also is defiled. —The verb is used of blood-guiltiness in Numbers 35:33, of impurity in Jeremiah 3:1-2; Jeremiah 3:9. It includes, therefore, all the sins that, in modern phrase, desecrate humanity. Taking the word in its wider range, each form of evil was a transgression of the everlasting covenant of Genesis 9:16.