Charles Ellicott Commentary Isaiah 43:28

"Therefore I will profane the princes of the sanctuary; and I will make Jacob a curse, and Israel a reviling." — Isaiah 43:28 (ASV)

I have profaned the princes of the sanctuary. —Better, holy princes. The title is given to the chief priests in 1 Chronicles 24:5. In the exile their priestly functions were in abeyance. They were practically desecrated.

The curse. —The cherem, or ban, answering to the anathema. The state described answers to that of Hosea 3:4.