Charles Ellicott Commentary Isaiah 50:2

"Wherefore, when I came, was there no man? when I called, was there none to answer? Is my hand shortened at all, that it cannot redeem? or have I no power to deliver? Behold, at my rebuke I dry up the sea, I make the rivers a wilderness: their fish stink, because there is no water, and die for thirst." — Isaiah 50:2 (ASV)

Wherefore, when I came...? — The "coming" of Jehovah must be taken in all its width of meaning. He came in the deliverance from Babylon, in a promise of still greater blessings, in the fullest sense, in and through His Servant, and yet no one came to help in the work or even to receive the message. (Compare to Isaiah 63:3.)

Not that He needed human helpers. In words that remind us, in their sequence, of the phenomena of the plagues of Egypt, the prophet piles up the mighty works of which He is capable. These words are echoed in Revelation 6:12; Revelation 8:9; Revelation 8:12.