Charles Ellicott Commentary Isaiah 53:6

"All we like sheep have gone astray; we have turned every one to his own way; and Jehovah hath laid on him the iniquity of us all." — Isaiah 53:6 (ASV)

All we like sheep have gone astray ... —The confession of repentant Israel (Psalms 119:176), of repentant humanity (1 Peter 2:25), was also the thought present to the mind of the Servant, as in Matthew 9:36; John 10:11.

Has laid on him. —Better, as in the margin, has made to light on him. The words express the fact, but do not explain the mystery, of the substitutive satisfaction. The two sides of that mystery are stated in the form of a seeming paradox. God does not punish the righteous with the wicked (Genesis 18:25). He accepts the suffering of the righteous for the wicked (Mark 10:45).