Charles Ellicott Commentary Jeremiah 19:4

"Because they have forsaken me, and have estranged this place, and have burned incense in it unto other gods, that they knew not, they and their fathers and the kings of Judah; and have filled this place with the blood of innocents," — Jeremiah 19:4 (ASV)

Have estranged this place. — i.e., have alienated it from Jehovah its true Lord, and given it to a strange god. The words refer specially to the guilt of Manasseh (2 Chronicles 33:4).

The blood of innocents. — The words seem at first to refer to the Molech sacrifices, which had made the valley of Hinnom infamous. These, however, are mentioned separately in the next verse, and the prophet probably spoke rather here, as in Jeremiah 2:34; Jeremiah 7:6, of the innocent blood with which Manasseh had filled Jerusalem (2 Kings 21:16; 2 Kings 24:4, where the same word is used).