Charles Ellicott Commentary Mark 1:24

"saying, What have we to do with thee, Jesus thou Nazarene? art thou come to destroy us? I know thee who thou art, the Holy One of God." — Mark 1:24 (ASV)

What have we to do with thee?—The cry is identical with that of the Gadarene demoniacs (Matthew 8:29). Here, as there, the possessed man has a preternatural intuition of our Lord’s greatness.

The Holy One of God.—The name occurs, as applied to Christ, only here, in the parallel passage of Luke 4:34, and in the better manuscripts of John 6:69. It probably had its origin in the Messianic application of Thy Holy One in Psalms 16:10. Its strict meaning is “the Holy One whom God owns as such,” who has attained, i.e., the highest form of holiness.