Charles Ellicott Commentary Revelation 16:21

"And great hail, [every stone] about the weight of a talent, cometh down out of heaven upon men: and men blasphemed God because of the plague of the hail; for the plague thereof is exceeding great." — Revelation 16:21 (ASV)

And there fell. . . .—And a great hail, as of a talent in weight, descends from the heaven on men. There is again a reference to the Egyptian plagues. But we may also call to mind the great defeat of the enemies of Israel at Beth-horon (Joshua 10:1–11), when the Lord cast down great stones from heaven.

Such an overthrow awaits every confederacy that arrays itself against the kingdom of the righteous King. The discomfiture and the plague work no repentance; the men blaspheme God because of the hail, for great is its plague exceedingly. The proud, hard spirit which still hates the good remains: thus sin is its own worst penalty. As an illustration of this hard, unsubdued spirit, we may call to mind Capaneus, in Dante’s Inferno, and the words in which Virgil addresses him:—

“You are more punished, in that this your pride
Lives yet unquenched; no torment except your rage
Would be pain fully proportioned to your fury.”

The unrepentant state of those upon whom the vials are poured is to be contrasted with the different result of the earthquake in Revelation 11:13, when men gave glory to the God of heaven.