Charles Spurgeon Commentary Luke 22:44

"And being in an agony he prayed more earnestly; and his sweat became as it were great drops of blood falling down upon the ground." — Luke 22:44 (ASV)

And his sweat was as it were great drops of blood falling down to the ground.

Luke was a physician, you know, so he was the most likely one to record this phenomenon. It has happened—so we have been told—to some other persons in intense fright or agony, that their sweat has been tinged with blood; but we never remember reading or hearing of anyone but our Lord of whom it could be said, His sweat was as it were great drops of blood falling down to the ground.

And being in an agony he prayed more earnestly: and his sweat was as it were great drops of blood falling down to the ground.

The Greek has the idea of the stretching of the sinews; Christ prayed to the very stretching of his nerves and sinews. As when men wrestle for their lives, so Christ in prayer strained every power of mind and body that he might prevail.

Luke alone describes this dread scene of Christ's agonizing even to blood; but there is no doubt whatever, from this passage, that our Lord Jesus actually sweated blood—not something like blood, but blood itself—and that it was in great drops and in such quantities that it not only adhered to his flesh and dyed all his garments, but there was such an abundance of it that in great drops it fell to the ground.