Charles Spurgeon Commentary Luke 22:45

"And when he rose up from his prayer, he came unto the disciples, and found them sleeping for sorrow," — Luke 22:45 (ASV)

And when he rose up from prayer, and was come to his disciples, he found them sleeping for sorrow,

Great sorrow may have quite opposite effects upon different men. You have, perhaps, sometimes noticed that intoxication produces upon some men exactly the opposite effect to that which it produces upon others; some become irritable and noisy, while others become taciturn and quiet. It is also quite a matter of fact that great sorrow has various effects upon different minds. In the Saviour's case, it aroused him to an awful agony of earnestness in prayer. In the disciples' case, it sent them to sleep.