Expositor's Bible Commentary Commentary Revelation 16:3

"And the second poured out his bowl into the sea; and it became blood as of a dead man; and every living soul died, [even] the things that were in the sea." — Revelation 16:3 (ASV)

The second bowl turns the sea into polluted blood . Genesis 1:21 is reversed; all marine life dies (cf. Exodus 7:17–21).