John Calvin Commentary 1 Corinthians 16:11

"let no man therefore despise him. But set him forward on his journey in peace, that he may come unto me: for I expect him with the brethren." — 1 Corinthians 16:11 (ASV)

Let no man, therefore, despise him. Here we have a second charge, that they may not despise him—perhaps because he was still of a youthful age, which usually draws less respect. He wants them, therefore, to take care that there be no hindrance to this faithful minister of Christ being held in due esteem—unless, perhaps, Paul considered this very thing to be an evidence of contempt if they were not concerned, as was fitting for them, regarding his life. This injunction, however, appears to include something further: that they should not undervalue Timothy from ignorance of his worth.

In the third place, he charges them to conduct him forward in peace, or, in other words, safe from all harm, for peace here means safety.