John Calvin Commentary Acts 22:10

"And I said, What shall I do, Lord? And the Lord said unto me, Arise, and go into Damascus; and there it shall be told thee of all things which are appointed for thee to do." — Acts 22:10 (ASV)

What shall I do, Lord? This is the voice of a humbled man, and this is the true turning to the Lord; when setting aside all fierceness and anger, we willingly bow our necks to bear his yoke and are ready to do whatever he commands us. Moreover, this is the beginning of doing good: to ask God directly for his word; for the labor of those who consider repentance without his word is lost. Furthermore, in appointing Ananias to be Paul’s teacher, Christ does not do so out of any reproach, nor because he himself refuses to teach him; rather, by this means he intends to establish and also to adorn the external ministry of the Church.

And even in the person of one man, he teaches us that we must not be reluctant to hear him speak through the words of men. To the same end also tends what immediately followed: that he was blind until, by offering himself to become a disciple, he had demonstrated the humility of his faith. God does not indeed make blind all those whom he intends to enlighten; but a general rule is prescribed for everyone: those who wish to be wise before him must become foolish in their own eyes.