John Calvin Commentary Genesis 27:45

"Until thy brother`s anger turn away from thee, and he forget that which thou hast done to him. Then I will send, and fetch thee from thence. Why should I be bereaved of you both in one day?" — Genesis 27:45 (ASV)

Why should I be deprived of you both in one day? Why does Rebekah fear a double loss? For there was no danger that Jacob, endowed with a disposition so mild and placid, would rise up against his brother. We see, therefore, that Rebekah concluded that God would be the avenger of the wicked murder.

Moreover, although God, for a time, might seem to overlook the deed and suspend His judgment, it would still be necessary for Him to withdraw from the murderer of kin. Therefore, by this law of nature, Rebekah declares that she would be entirely bereaved, because she would be compelled to dread and detest the one who survived.

But if Rebekah anticipated in her mind what the judgment of God would be, and devoted the murderer to destruction because she was persuaded that such great wickedness would not go unpunished, much less should we close our eyes to the manifest chastisements of God.