John Calvin Commentary Isaiah 57:21

"There is no peace, saith my God, to the wicked." — Isaiah 57:21 (ASV)

There is no peace to the wicked. He confirms the preceding statement: that the reprobate will strive in vain to seek peace, for everywhere they will meet with war. It is God who threatens war, and therefore there can be no hope of "peace."

Wicked men would indeed wish to enjoy peace and ardently long for it, for there is nothing they more eagerly desire than to be at ease and to lull their consciences, so that they may freely take their pleasures and indulge in their vices. They drive away all thoughts about the judgment of God, strive to stupefy themselves, and rest in indolence, thinking that these are the best ways and methods of obtaining peace. But they will never enjoy it, for until people have been reconciled to God, conscience will never cease to trouble them and carry on war with them.

Saith my God. Thus he represents God as the only author of peace, so that by this dreadful threatening, He may tear from the Jews their dearest pleasures; and he calls Him "his God," in opposition to the vain boasting of those who falsely boasted of His name, for they cannot acknowledge God as long as they reject His Prophet and His doctrine. For this reason, the Prophet boldly declares that he has received a command from God to declare perpetual war against them.

CHAPTER 58.