John Calvin Commentary Isaiah 6:12

"and Jehovah have removed men far away, and the forsaken places be many in the midst of the land." — Isaiah 6:12 (ASV)

Till the Lord have removed men far away. These words contain nothing new, but are merely an explanation of the previous verse, and a description in other words of the ruin that will overtake Judea: namely, that God will send the inhabitants far away.

He asserts that those who survive the war will not be exempt from punishment, for they will be led into captivity.

Next, he adds a general clause about the desolation of the land, as if he had said that it would be desolate and bereft of inhabitants, because some would flee, others would be driven into exile, and others would perish by the sword.

Such is the reward prepared for obstinate and rebellious people, who add crime to crime, until the indignation of God rises to such a height that it cannot be appeased.