John Calvin Commentary Jeremiah 50:13

"Because of the wrath of Jehovah she shall not be inhabited, but she shall be wholly desolate: every one that goeth by Babylon shall be astonished, and hiss at all her plagues." — Jeremiah 50:13 (ASV)

Jeremiah again repeats that the destruction of Babylon would be an evidence of God’s vengeance, because the Chaldeans had unjustly raged against the Church.

But the name of God also seems to have been intentionally mentioned, so that the faithful could more readily receive this prophecy. For if they had thought that what Jeremiah said came from man, they would have hardly believed his words, because what he said exceeded human comprehension.

He then mentioned the indignation of God, so that the faithful would know that it was absurd to form an opinion about the ruin of Babylon based on how things currently appeared, because God would perform a work there beyond the ordinary course of events.

He then says that it would become a waste, so that everyone passing through it would be astonished, and yet would not pity it. This manner of speaking often occurs in the Prophets when they wish to describe a desolation exceeding what is common. Meanwhile, it should also be noted what follows: that this situation would provoke no pity, but rather mockery, which the Prophet denotes by the word hissing.