John Calvin Commentary John 15:21

"But all these things will they do unto you for my name`s sake, because they know not him that sent me." — John 15:21 (ASV)

But all these things they will do to you. Since the fury of the world is monstrous when it is so enraged against the doctrine of its own salvation, Christ explains that it is hurried on by blind ignorance to its own destruction; for no one would deliberately engage in battle against God.

It is blindness and ignorance of God, therefore, that hurries on the world, so that it does not hesitate to make war with Christ.

We should, then, always observe the cause of this conduct, and true consolation consists in nothing other than the testimony of a good conscience. It should also excite gratitude in our minds that while the world perishes in its blindness, God has given us his light.

Yet let it be understood that hatred of Christ arises from stupidity of mind when God is not known; for, as I have often said, unbelief is blind; not that wicked men do not understand or know anything, but because all the knowledge that they have is confused and quickly vanishes.

I have treated this subject more extensively elsewhere.