John Calvin Commentary Philippians 4:22

"All the saints salute you, especially they that are of Caesar`s household." — Philippians 4:22 (ASV)

The brethren that are with me salute you. In these salutations, he names first of all his intimate associates, afterwards all the saints in general (that is, the whole Church at Rome), but chiefly those of the household of Nero—a point well worth noting, for it is remarkable evidence of divine mercy that the gospel had found its way into that cesspool of all crimes and iniquities.

It is also all the more admirable, especially since it is rare for holiness to reign in the courts of sovereigns.

The conjecture by some that Seneca is referred to here among others has no apparent basis, for he never gave even the slightest evidence of being a Christian. Nor did he belong to the household of Caesar; rather, he was a senator and had at one time held the office of praetor.