John Gill Commentary 2 Kings 21:16

"Moreover Manasseh shed innocent blood very much, till he had filled Jerusalem from one end to another; besides his sin wherewith he made Judah to sin, in doing that which was evil in the sight of Jehovah." — 2 Kings 21:16 (ASV)

Moreover, Manasseh shed innocent blood very much
Putting to death the prophets that reproved him and his people for their idolatries, and such who would not comply therewith; and it is commonly said, both by Jewish and Christian writers, that Isaiah was slain, and even sawn asunder by him, (See Gill on Hebrews 11:37),

till he had filled Jerusalem from one end to another ;
a metaphor taken from filling a vessel brimful:

beside his sin wherewith he made Judah to sin, in doing that which was
evil in the sight of the Lord ;
the sin of idolatry he drew them into, and even obliged them to commit.