John Gill Commentary Acts 3:17

"And now, brethren, I know that in ignorance ye did it, as did also your rulers." — Acts 3:17 (ASV)

And now, brethren He calls them brethren, because they were so according to the flesh; and to testify his cordial love and affection for them.

I know, that through ignorance you did it; delivered up Jesus into the hands of Pilate; denied him to be the Messiah before him; preferred a murderer to him, and put him to death.

As did also your rulers; the members of the sanhedrim, some of them; see (1 Corinthians 2:8) for others of them knew him to be the Messiah, to be sent of God, by the miracles he did, and yet blasphemously ascribed them to Satan; and so sinning against light and knowledge, in such a malicious manner, sinned the sin against the Holy Ghost, to which ignorance is here opposed; and which did not excuse from sin: nor was it itself without sin; nor is it opposed to any sin, but to this now mentioned.