John Gill Commentary Ezekiel 16:45

"Thou art the daughter of thy mother, that loatheth her husband and her children; and thou art the sister of thy sisters, who loathed their husbands and their children: your mother was a Hittite, and your father an Amorite." — Ezekiel 16:45 (ASV)

You [are] your mother's daughter.
Exactly like her; they that have known the one must know the other. The Targum is, ``wherefore are you become the daughter of the land of Canaan, to do according to the works of the people?''

That loathes her husband and her children.
A true character of an adulteress; and which agrees both with the mother the Canaanites, and with the daughter the Jews; who both despised, rejected, and forsook God their husband, Creator, and lawgiver, and sacrificed their children to idols; see (Ezekiel 16:20Ezekiel 16:21) (Leviticus 18:21Leviticus 18:24).

And you [are] the sister of your sisters.
The true genuine sister of them, Samaria and Sodom after mentioned; being not only allied to them in blood, more nearly to the one more remotely to the other, but exceedingly alike in manners, religion, and worship.

Which loathes their husbands and their children.
As before.

Your mother [was] an Hittite, and your father an Amorite.
These the Israelites succeeded in their land, and followed their customs; (See Gill on Ezekiel 16:3). The Targum is, ``was not your mother Sarah among the Hittites? and she did not do according to their works; and your father Abraham was among the Amorites, and he walked not in their counsels.''